Transient cerebral ischaemia alters mesenteric arteries in hypertensive rats: Limited reversal despite suberoylanilide hydroxamic acid cerebroprotection

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Transient cerebral ischaemia alters mesenteric arteries in hypertensive rats: Limited reversal despite suberoylanilide hydroxamic acid cerebroprotection

Authors: Díaz-Pérez A, Lope-Piedrafita S, Pérez B, Vázquez-Sufuentes P, Rodriguez-Garcia M, Briones AM, Navarro X, Penas C, Jiménez-Altayó F.

Citation: Life Sci. 2024 Dec 15:359:123247
DOI: 10.1016/j.lfs.2024.123247

Summary: The study shows that transient cerebral ischemia causes persistent structural and functional changes in mesenteric arteries of hypertensive rats. Even with cerebroprotection using suberoylanilide hydroxamic acid (SAHA), arterial dysfunction is only partially reversed, suggesting systemic vascular effects of cerebral ischemia.

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