Authors: Belakova B, Basílio J, Campos-Medina M, Sommer AFP, Gielecińska A, Resch U, et al. Cells. 2025;14(11).
Summary: Our study found that both replicative and radiation-induced senescence, as well as chronic inflammation of endothelial cells, lead to increased expression of genes linked to epithelial/endothelial mesenchymal transition (EMT) and inflammatory pathways, resulting in reduced cell proliferation and elevated secretion of cytokines such as IL-6 and IL-8. Chronic inflammation amplified EMT features, while acute inflammation mainly triggered classical inflammatory responses; functionally, senescent and chronically inflamed cells also showed impaired wound healing. These findings highlight how inflammation exacerbates senescence-associated changes and suggest new directions for therapies targeting age-related cardiovascular diseases.
