Circular RNA role inAtherosclerosis Development and Progression.

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Circular RNA role inAtherosclerosis Development and Progression.

Authors: Greco S, Gaetano C, Mazzaccaro D, Martelli F.

Citation: Curr Atheroscler Rep. 2025 Jun 3;27(1):60.
DOI: 10.1007/s11883-025-01306-x

Summary: This review explores both experimental and in vivo findings on the functions of specific circularRNAs (circRNAs) and their involvement in cellular autophagy, apoptosis, oxidative stress, and vascular remodeling. Additionally, the diagnostic potential of circulating circRNAs as biomarkers for plaque instability and rupture has been investigated. Understanding circRNA-mediated regulatory networks may open new avenues for precision diagnostics and targeted therapies in atherosclerotic cardiovascular disease.

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