Metagenomic analysis of atheroma plaques for identification of microorganisms indicates presence of Toxoplasma gondii as a possible etiological agent

Authors: Feyzanur Erdemir, Ahmet Karabulut, Unal Aydin, Salih Güler, Aysenur Cicek, Selcen Necibe Gokduman, Ecem Eser, Selçuk Birdoğan, Tanıl Kocagöz

DOI: https://doi.org/10.1016/j.jiph.2024.102539

Summary: This study provides the first metagenomic evidence supporting the presence of Toxoplasma gondii DNA within human atheroma plaques. The findings suggest a possible etiological role of this protozoan parasite in the development of atherosclerosis. These results emphasize the importance of investigating infectious agents as potential contributors to chronic cardiovascular diseases.