Sex- and age-dependent neurovascular abnormalities linked to neuroinflammation lead to exacerbated post-ischemic brain injury in Marfan syndrome mice

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Sex- and age-dependent neurovascular abnormalities linked to neuroinflammation lead to exacerbated post-ischemic brain injury in Marfan syndrome mice

Authors: Manich G, Pérez B, Penas C, Dantas AP, Coutinho J, Sánchez-Bernadó P, García-Aranda J, Fraile-Ramos J, Benseny-Cases N, Martín-Mur B, Esteve-Codina A, Rodríguez-Rovira I, Giménez-Llort L, Egea G, Jiménez-Altayó F.

Citation: Redox Biol. 2025 Jun:83:103662
DOI: 10.1016/j.redox.2025.103662

Summary: This work demonstrates that Marfan syndrome mice exhibit sex- and age-dependent neurovascular abnormalities that exacerbate post-ischemic brain injury. Neuroinflammation contributes to the heightened vulnerability, emphasizing the importance of considering sex and age when modeling cerebrovascular complications in connective tissue disorders.

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